1 Mataxe

Nicoumalone Classification Essay

The British Medical Journal


Coverage: 1857-1980 (Vol. 1, No. 1 - Vol. 281, No. 6256)

Moving Wall: 3 years (What is the moving wall?)

The "moving wall" represents the time period between the last issue available in JSTOR and the most recently published issue of a journal. Moving walls are generally represented in years. In rare instances, a publisher has elected to have a "zero" moving wall, so their current issues are available in JSTOR shortly after publication.
Note: In calculating the moving wall, the current year is not counted.
For example, if the current year is 2008 and a journal has a 5 year moving wall, articles from the year 2002 are available.

Terms Related to the Moving Wall
Fixed walls: Journals with no new volumes being added to the archive.
Absorbed: Journals that are combined with another title.
Complete: Journals that are no longer published or that have been combined with another title.

ISSN: 00071447

Subjects: Medicine & Allied Health, Health Sciences

Collections: Health & General Sciences Collection, Life Sciences Collection


Over the years a number of excellent books have classified and detailed drug­ drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering intestinal absorption or bioavailability; those involving hepatic metabolising enzymes; those involving competition or antagonism for receptor sites, and drug interactions modifying excretory mechanisms. Such books have presented extensive tables of interactions and their management. Although of considerable value to clinicians, such publica­ tions have not, however, been so expressive about the individual mechanisms that underlie these interactions. It is within this sphere of "mechanisms" that this present volume specialises. It deals with mechanisms of in vitro and in vivo, drug-drug, drug­ food and drug-herbals interactions and those that cause drugs to interfere with diagnostic laboratory tests. We believe that an explanation of the mechanisms of such interactions will enable practitioners to understand more fully the nature of the interactions and thus enable them to manage better their clinical outcome. If mechanisms of interactions are better understood, then it may be pos­ sible for the researcher to develop meaningful animal/biochemical/tissue cul­ ture or physicochemical models to which new molecules could be exposed during their development stages. The present position, which largely relies on patients experiencing adverse interactions before they can be established or documented, can hardly be regarded as satisfactory. This present volume is classified into two major parts; firstly, pharmacoki­ netic drug interactions and, secondly, pharmacodynamic drug interactions.


Filtration Wechselwirkung absorption amino acid chemotherapy drug enzyme enzymes kidney metabolism pharmacodynamics pharmacokinetics pharmacology physiology steroids

Editors and affiliations

  • Patrick F. D’Arcy
  • James C. McElnay
  • Peter G. Welling
  1. 1.School of PharmacyThe Queen’s University of Belfast, Medical Biology CentreBelfastN. Ireland
  2. 2.School of PharmacyThe Queen’s University of Belfast, Medical Biology CentreBelfastN. Ireland
  3. 3.Pharmacokinetics and Drug MetabolismParke-Davis Pharmaceutical ResearchAnn ArborUSA

Bibliographic information

  • DOIhttps://doi.org/10.1007/978-3-642-61015-8
  • Copyright InformationSpringer-Verlag Berlin Heidelberg 1996
  • Publisher NameSpringer, Berlin, Heidelberg
  • eBook PackagesSpringer Book Archive
  • Print ISBN978-3-642-64658-4
  • Online ISBN978-3-642-61015-8
  • Series Print ISSN0171-2004
  • Series Online ISSN1865-0325
  • About this book

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